More On The Dangers of PPIs (Prilosec, Nexium, Prevacid)

It continues to become very clear that these medicines are doing serious harm to people.  Every week there is a new article with more information about the dangers of these medicines.

The following is from a recent article in the U.S. News & World Report.

Taking PPIs has been linked to an increased risk of pneumonia and a higher risk of developing a digestive system infection called clostridium difficile that causes diarrhea and can be life-threatening. In addition, PPIs can affect absorption of vitamins and minerals and have been found to be associated with certain deficiencies, such as for vitamin B12, calcium, iron and magnesium, says Dr. Joel Heidelbaugh, a clinical professor of family medicine at the University of Michigan—Ann Arbor, who has done research on the overutilization of PPIs and risks associated with this class of drugs. He notes there’s now also concern PPIs could possibly affect kidney function and be linked to a higher risk of developing chronic kidney disease. “Of course, all of these associations were determined retrospectively,” he says. The drugs haven’t been studied prospectively to prove a cause-and-effect relationship between taking PPIs and the health issues studied. But experts say the risks are worth considering when deciding whether to start or continue on PPIs.

Most recently, a study published online in April in the Journal of the American Society of Nephrology found patients who take PPIs for heartburn, acid reflux or ulcers were more likely to experience a decline in kidney function, compared to those taking H2 blockers, and had an increased risk of developing chronic kidney disease and kidney failure. Researchers found the longer patients took PPIs, the greater an individual’s risk. Regarding possible vitamin deficiencies associated with PPIs, Heidelbaugh notes in recent years that attention has turned toward magnesium. Low levels of magnesium have been linked to issues ranging from osteoporosis to high blood pressure. In addition, research published last year in the online open-access journal PLOS One found that taking PPIs was associated with an increased risk of heart attack.

I’m so glad I made the decision to stop taking this awful drug.  It still worries me that there may be residual damage after more than 20 years of taking it daily.   I have to tell you that at this point I have zero confidence in getting to the truth of it inside the medical world.

Several years back I expressed to my doctor my desire to quit this medicine, and his response was “why?  it seems to work well for you and there have been no long term damaging side effects noted, I would recommend you continue with it”

I like my doctor, I’ve been a patient of his for almost 20 years, and I plan to discuss this with him at my next visit and share with him my concerns and the entire weaning process I’ve gone through.  I want it specifically noted in my chart for future reference.

If you are still taking any of the PPI medications please discuss it with your doctor and perhaps consider this weaning process as an option for you too.  If you have any questions, suggestions or comments please share them with us.  You never know who it might help, after all it was a friend that shared her experience with me that encouraged me to quit these drugs.

Have a great day!

Till Next Time,

Lori

Omeprazole Update

Today is the beginning of week 7 of weaning myself off Omeprazole.  I have to say that it really hasn’t been bad at all.  I believe the L-Glutamine and digestive enzymes have helped it go smoothly.  After reading the book Eat Dirt by Dr. Axe I have self diagnosed myself with leaky gut syndrome.

Here is a little information on leaky direct from Dr. Axe’s book Eat Dirt:

What Is Leaky Gut Syndrome?

Think of the lining of your digestive tract like a net with extremely small holes in it that only allow specific substances to pass through. Your gut lining works as a barrier keeping out bigger particles that can damage your system. 

When someone has leaky gut (often referred to as increased intestinal permeability), the “net” in your digestive tract gets damaged, which causes even bigger holes to develop in your net, so things that normally can’t pass through, are now be able to.

Some of the things that can now pass through include proteins like gluten, bad bacteria and undigested foods particles. Toxic waste can also leak from the inside of your intestinal wall into your bloodstream causing an immune reaction.

Leaky Gut Symptoms and Progression

This leads to inflammation throughout your system and can cause symptoms, such as:

  • Bloating
  • Food sensitivities
  • Thyroid conditions
  • Fatigue
  • Joint pain
  • Headaches
  • Skin issues like rosacea and acne
  • Digestive problems
  • Weight gain
  • Syndrome X

Dr. Axe also states in his book that leaky gut can be attributed to long term usage of medicines such as Nexium, Prilosec, Omeprazole (generic Prilosec).  Well hello, I’ve been taking Prilosec or Omeprazole for over 20 years.

A few things I’ve learned while weaning off of the Omeprazole are:

  • Daily stomach pain, cramping and bloating is not normal.
  • Portion control of every meal is important in eliminating acid reflux.  This was especially hard for me because I’ve never specifically portioned food, I just filled the imaginary sections of the plate.  I also ate untill I was full, which by that time was too late, I had already overeaten.
  • Drinking a good amount of water through out the day, but limit beverages during meals.
  • Allow plenty of time for digestion before bedtime and try to prop yourself up a bit when sleeping.  I start out that way but end up always sliding down in the bed during the night.

So this is where I am in the process.  Last week I did experience some discomfort but it was directly related to some foods that I ate.  I can add white pasta to the list of things that are difficult for me to digest.    I did fine with the honey wheat bread I made, and honestly I didn’t have any issue with the buns I bought for our hamburgers, so I don’t believe it’s a gluten intolerance.  But something about boxed white pastas causes me discomfort.  Looks like I’m going to need the pasta attachment for my kitchen aid. 😉

I’ve been putting some probiotic fermented whey lemonade in my morning water.  I got my recipe for fermented whey lemonade from http://www.thehealthyhomeeconomist.com/ I love her website as it is filled with a lot of great information and videos.

This is going to be a long, well actually it’s going to be a lifetime process for me.  Changing my diet from where it was to where it needs to be with organic real foods, quality over quantity and eliminating the chemicals from our lives as much as possible.

Today I started the lower dosage of removing 175 of the 200 little balls in the 40mg Omeprazole capsule, which means in next week I’ll start the every other day process for a week and then hopefully I’ll have completed the weaning process ( I hope, I hope, I hope).

Have A Great Day!

Till Next Time,

Lori

 

 

Proton Pump Inhibitors Linked To Kidney Disease

This is the article from MSN – Medical Daily

Taking OTC Meds For Heartburn, Acid Reflux May Just Lead To Other Problems

Common over-the-counter acid reflux and heartburn medications may be causing kidney failure in its users.

Every year, doctors prescribe medications to patients who complain of heartburn, acid reflux, or ulcers, and roughly 15 million Americans are given a class of drugs that can cause some serious, long-term damage to their kidneys. Researchers at the Clinical Epidemiology Center at the VA Saint Louis Health Care System and Washington University in Saint Louis zeroed in on proton pump inhibitors (PPI), one of the most widely sold and over-prescribed drugs in the world, to not only confirm from previous findings that it leads to kidney disease, but that it also led to renal failure at an alarming rate.

The results emphasize the importance of limiting PPI use only when it is medically necessary, and also limiting the duration of use to the shortest duration possible,” said the study’s lead author Dr. Ziyad Al-Aly, a professor of medicine at Washington University School of Medicine, in a statement. “A lot of patients start taking PPIs for a medical condition, and they continue much longer than necessary.”

For the study, researchers selected 173,321 new users of PPIs, 20,270 new users of histamine H2 receptor blockers, which are in another class of medications that are also used as an acid suppressing regimen. They spent five years following up with the patients, who were selected from the Department of Veterans Affairs national databases. Their findings, published in the Journal of the American Society of Nephrology, reveal PPIs have the propensity to increase the risk of chronic kidney disease by 28 percent and developing kidney failure by 96 percent. They found the longer the patients took the drugs, the greater they put themselves at risk for kidney damage.

Recently, researchers from Johns Hopkins University published a study in JAMA ’s February 2016 edition that found the same risk exists between PPI use and chronic kidney disease. Not only do the results from Al-Aly and his team confirm the cause-and-effect between PPI use and chronic kidney disease, but they took their study a step further and found the medication also drastically increases the risk of developing kidney failure. To make matters worse, PPIs are also available over the counter.

“You or I could go to Walgreens or CVS and get Prilosec or other PPI medication over the counter and it has the same risks as prescription,” Al-Aly told Medical Daily. “We all assume that what we get over the counter is absolutely safe, I don’t have to worry about it because the FDA must have done their due diligence. But we’re finding with these medicines there is quite a negative effect and it should not be ignored, cannot be ignored.”

Medications like Prilosec put users at an elevated risk for developing kidney disease and renal failure. © Photo courtesy of Mario Villafuerte/ Getty Images Medications like Prilosec put users at an elevated risk for developing kidney disease and renal failure. PPIs are a relatively new class of drug with highly limited long-term studies until now. Previously, patients with acid reflux relied on H2 blockers for acid reflux, however PPI drugs were seen as the more powerful and effective option for treating acid reflux. PPI drugs can be both prescribed and purchased over the counter — in strengths that both cause the same level of damage to the kidneys. Researchers recommend PPIs should be avoided, especially when acid reflux or the like can easily be treated with kidney-safe H2 blockers.

“Since PPI inhibitors are associated with this effect but the H2 blockers are not, I think that’s a useful control and gives legitimacy to the finding,” Dr. David Goldfarb, the clinical chief of nephrology and professor of medicine at NYU Langone Medical Center, told Medical Daily. “When they are able to look at another group of drugs used for similar indication and see that they don’t demonstrate an effect on kidney function; that makes their findings incredible.”

Researchers aren’t quite sure why PPIs have such a negative effect on the user’s kidneys. Al-Aly and his research team can only speculate it may have to do with patients who were at a higher level of risk because they had acute kidney injury or interstitial nephritis, which is inflammation of the kidney tubules, both of which could lead to renal failure.

“This is really the subject of ongoing investigation now so I cannot determine definitively. We’re just scratching the surface here,” Al-Aly said. “Next, we need to determine if there are any genetic markers that could predispose a patient to kidney disease progression with PPI use.”

Source: Al-Aly Z, Xie Y, Li T, and Balasubramanian S. Proton Pump Inhibitors and Risk of Incident and Progression of Chronic Kidney Disease and ESRD . Journal of the American Society of Nephrology. 2016.

I’m not sure why it states in the article that PPI drugs are a relatively new class of drug, because I’ve been taking Prilosec or the generic version of it for about 20 years.  However, I’m not at all surprised about it’s “highly limited long term study”  It’s about money people! 

Honestly, who can you trust?

Trust yourself, do the research, buy organic, eat clean and eat real food.  Read labels, make sure it’s ingredients you can pronounce and understand and keep it to five or less ingredients.

Cook your own food as much as possible, and buy foods as local and with as little packaging as possible.

I hear people all the time saying organic is so much more expensive.  My response to that is you’re either going to pay for it now or pay for it later with poor health and medical bills. 

We have got to get off of these medicines, NOW!

You can follow along with my “Weaning Off Of Omeprazole” by clicking on the Omeprazole tag and it will take you to all of the post detailing the process I’m using. 

Take Care, Friends!

Lori

 

What’s Cooking 4/12/16?

This morning before I left for work I filled the crock pot with everything to make drip beef or Mississippi pot roast (they are both about basically the same recipe).  But, instead of using beef I used venison and added a couple heaping teaspoons of bacon fat in it.  Fat is good people, fat is good 🙂

I grabbed my breakfast and lunch and left the house without taking my omeprazole, L-Glutamine, coconut oil, or turmeric.  We’ll see what happens.  This could inadvertently speed up the weaning off omeprazole process.  Yesterday I started taking an even lower dosage that calculates to 20mg which is half of my prescribed amount.

I was in a hurry to get the dinner dishes done, kitchen cleaned, and breakfast and lunches made last night so I could settle in and start on a few library books I picked up yesterday.  Joel Salatin is an American farmer whose is the owner and operator of Polyface Farm in Swoope, Virginia.  He is the author of many books regarding alternative farming, often calling himself a grass farmer, letting the animals do all the work of tending to the farming processes without industrial pesticides or fertilizers.  He is doing it the right way y’all.

Anyway… apparently I was in too much of a hurry because as I was making my overnight oats, I forgot to put the tablespoon of maple syrup in them.  I didn’t realize it of course till this morning….

Here is a picture of my breakfast and lunch for today (and my love for wide mouth mason jars, of all sizes) 🙂

 

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But after my first bite of unsweetened overnight oats, I decided to save that till tomorrow when I can properly sweeten it and instead I went with this….

Honey wheat bread with peanut butter and jelly.

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  • Breakfast: honey wheat bread with peanut butter and jelly and a apple
  • Lunch: salad in a jar with a creamy avocado dressing that I experimented with last night and turned out lovely.
  • Dinner: Z’s venison with mashed potatoes and roasted asparagus

Sometimes I include recipes sometimes I don’t… if you ever want one of my recipes just let me know and I’ll gladly share it.  🙂

Y’all have a great day!

Till Next Time,

Lori